Biosynthesis of Hyaluronate
نویسندگان
چکیده
منابع مشابه
Distribution of hyaluronate and hyaluronate receptors in the adult lung.
In the present study, we have examined the distribution of both hyaluronate receptors and hyaluronate in adult hamster lung. The receptor for hyaluronate is a transmembrane glycoprotein of Mr 85,000 that interacts with actin filaments and is thought to mediate many of the effects that hyaluronate has on cell behaviour, such as cell-to-cell adhesion and migration. It was localized histochemicall...
متن کاملInhibition of hyaluronate synthesis.
UDP-GlcNAc (UDP-N-acetylglucosamine) and UDP-GlcA (UDP-glucuronic acid) were oxidized by periodate in the ribose ring and utilized as inhibitors for hyaluronate synthase in membrane fractions from the B6 cell line and in cell cultures of B6 cells and human fibrosarcoma HT 1080. Inhibition was irreversible and concentration-dependent and could be prevented in the case of periodate-oxidized UDP-G...
متن کاملDetermination of synovial fluid hyaluronate
High performance liquid chromatography (HPLC) with a size exclusion column and ultraviolet monitoring was used to study the effect of synovial fluid hyaluronate concentration and degree of polymerisation on viscosity and mucin clot formation. Rotational viscometry measurements showed an exponential relation between the synovial fluid hyaluronate concentration and relative viscosity, the viscosi...
متن کاملIsolation of streptococcal hyaluronate synthase.
Hyaluronate synthase was isolated from protoblast membranes of streptococci by Triton X-114 extraction and cetylpyridinium chloride precipitation. It was identified as a 52,000-Mr protein, which bound to nascent hyaluronate and was affinity-labelled by periodate-oxidized UDP-glucuronic acid and UDP-N-acetylglucosamine. Antibodies directed against the 52,000-Mr protein inhibited hyaluronate synt...
متن کاملHyaluronate gel stapedotomy.
OBJECTIVE To evaluate hearing results and postoperative dizziness after stapedotomy with application of sodium hyaluronate gel (HG) to the oval window niche during fenestration of the footplate. STUDY DESIGN Case-control study comparing 27 stapedotomies with HG and 32 stapedotomies without HG. OUTCOME MEASURE Preoperative and postoperative audiometric data, postoperative dizziness (vertigo ...
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ژورنال
عنوان ژورنال: Nature
سال: 1955
ISSN: 0028-0836,1476-4687
DOI: 10.1038/175435a0